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HRID 410973作成日：2026年10月25日

Isobutylene oxide → 1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid [2-(2-hydroxy-2-methyl-propoxy)-ethyl]-amide

https://huagongshe.com/reaction/410973

反応式

関与物質

役割名称HCID仕込み量
反応物Isobutylene oxideHCID 11208—
反応物Potassium HydroxideHCID 14797—
反応物1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethyl)-amideHCID 86656751—
溶媒DimethylformamideHCID 6228—
生成物1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid [2-(2-hydroxy-2-methyl-propoxy)-ethyl]-amideHCID 866568934.3%

反応手順

1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid [2-(2-hydroxy-2-methyl-propoxy)-ethyl]-amide (5 mg) was prepared by following General Procedure X starting from 1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethyl)-amide (100 mg), 1,2-epoxy-2-methyl-propane (19 mg), and KOH (19 mg) in DMF. LC/MS: m/z 524.7.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08759535B2
出典データセットuspto-grants-2014_06
ORD IDord-f61e05a01c6f4abb984df8d2e87c8885
出典メモuspto-grants-2014_06