HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Chloroethyl)dibenzylamine → [2-(2-Dibenzylamino-ethoxy)-ethyl]methyl-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Chloroethyl)dibenzylamine | HCID 5820 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol | HCID 545700 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [2-(2-Dibenzylamino-ethoxy)-ethyl]methyl-carbamic acid tert-butyl ester | HCID 67332450 | 32.6% |
Reaction Steps
[2-(2-Dibenzylamino-ethoxy)-ethyl]-methyl-carbamic acid tert-butyl ester (200 mg) was prepared by following General Procedure S starting from dibenzyl-(2-chloro-ethyl)-amine (400 mg), (2-hydroxy-ethyl)-methyl-carbamic acid tert-butyl ester (525 mg), 50% (w/w) KOH solution (1.8 mL) and tetrabutylammonium bromide (57.7 mg) in dioxane (1.8 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-843280e7221d4553b5e61ad4043f6770 |
| Source note | uspto-grants-2014_06 |