HCID 86656910, compound → HCID 86656911, compound

HRID 410997Notes

Reaction equation

HRID 410997 reaction equation
[C:1]([O:5][C:6](=[O:28])[N:7]([CH2:11][CH2:12][N:13](CC1C=CC=CC=1)CC1C=CC=CC=1)[CH2:8][CH2:9][F:10])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:28])[N:7]([CH2:11][CH2:12][NH2:13])[CH2:8][CH2:9][F:10])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 86656910HCID 86656910, compound

Product 1

HCID 86656911HCID 86656911, compoundYield 82.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(2-Amino-ethyl)-(2-fluoro-ethyl)-carbamic acid tert-butyl ester (95 mg) was prepared by following General Procedure T starting from (2-dibenzylamino-ethyl)-(2-fluoro-ethyl)-carbamic acid tert-butyl ester (216 mg) and Pd—C (40 mg) in methanol (1 mL).

Sources & evidence

ORD record
ord-feb49cd7cf1747d4813c8bf6798cc471
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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