Sodium Hydroxide → 2-(6-Chloro-benzothiazol-2-ylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid

HRID 411006Notes

Reaction equation

HRID 411006 reaction equation
C([O:3][C:4]([C:6]1[CH:26]=[CH:25][C:9]2[N:10]=[C:11]([NH:14][C:15]3[S:16][C:17]4[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:18]=4[N:19]=3)[N:12]([CH3:13])[C:8]=2[CH:7]=1)=[O:5])C.[OH-].[Na+]>CO.C1COCC1>[Cl:24][C:22]1[CH:21]=[CH:20][C:18]2[N:19]=[C:15]([NH:14][C:11]3[N:12]([CH3:13])[C:8]4[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:26]=[CH:25][C:9]=4[N:10]=3)[S:16][C:17]=2[CH:23]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 866569172-(6-Chloro-benzothiazol-2-ylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid ethyl ester

Product 1

HCID 866569182-(6-Chloro-benzothiazol-2-ylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acidYield 89.8%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid (1 g) was prepared by following General Procedure E starting from 2-(6-chloro-benzothiazol-2-ylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid ethyl ester (1.2 g) and 2 N NaOH (5 mL) in methanol:THF (1:1, 20 mL).

Sources & evidence

ORD record
ord-60e82082ac1b4b398720bab7e3d48237
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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