HCID 67333443, compound → HCID 67332848, compound

HRID 411058Notes

Reaction equation

HRID 411058 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH3:14])=[C:6]([N+:22]([O-])=O)[CH:5]=1>CO.CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][N:13]([C:15]([O:17][C:18]([CH3:19])([CH3:21])[CH3:20])=[O:16])[CH3:14])=[C:6]([NH2:22])[CH:5]=1

Participants

4

Reactant 1

HCID 67333443HCID 67333443, compound

Product 1

HCID 67332848HCID 67332848, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

3-Amino-4-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-benzoic acid methyl ester (1.4 g) was prepared by following General Procedure B starting from 4-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-3-nitro-benzoic acid methyl ester (1.7 g) and Pd—C (350 mg) in methanol:EtOAc (1:1, 20 mL).

Sources & evidence

ORD record
ord-f8e0e68627f6434a8d4ace96d0019e2d
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

Loading…