Sodium Hydroxide → HCID 86656890, compound

HRID 411060Notes

Reaction equation

HRID 411060 reaction equation
C[O:2][C:3]([C:5]1[CH:35]=[CH:34][C:8]2[N:9]([CH2:23][CH2:24][N:25]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH3:26])[C:10]([NH:12][C:13]3[S:14][C:15]4[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:16]=4[N:17]=3)=[N:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+]>CO.C1COCC1>[C:30]([O:29][C:27]([N:25]([CH3:26])[CH2:24][CH2:23][N:9]1[C:8]2[CH:34]=[CH:35][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=2[N:11]=[C:10]1[NH:12][C:13]1[S:14][C:15]2[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:16]=2[N:17]=1)=[O:28])([CH3:33])([CH3:32])[CH3:31]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86656973HCID 86656973, compound

Product 1

HCID 86656890HCID 86656890, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

1-[2-(tert-Butoxycarbonyl-methyl-amino)-ethyl]-2-(6-chloro-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid (1.7 g) was prepared by following General Procedure E starting from 1-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-2-(6-chloro-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester (1.9 g) and 2 N NaOH (5 mL) in methanol:THF (1:1, 10 mL).

Sources & evidence

ORD record
ord-8cb7acf24c3e4eecbc23c56b04b37359
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

Loading…