HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Oxo-2,3-Dihydro-1H-Indene-4-Carbonitrile → 1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Oxo-2,3-Dihydro-1H-Indene-4-Carbonitrile | HCID 2751583 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile | HCID 14515307 | 80% |
Reaction Steps
To a stirred suspension of 1-oxo-2,3-dihydro-1H-indene-4-carbonitrile (1.0 equiv, 0.4M) and silica gel (catalytic) in ethanol at 0° C. was added NaBH4 (⅓ equiv). The reaction was allowed to warm up to room temperature and stirred for 2 h. The Solvent was removed under reduced pressure and the product purified by CC in hexane/EtOAc (5:5) to offer 1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile in 80% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530503B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-f407db76645f44768a3732405a2bd106 |
| Source note | uspto-grants-2013_09 |