反应详情

A solution of KOH (0.224 g, 4 mmol) in MeOH (3 mL) was added, over the course of 30 min, to a warmed (70° C.) mixture of 1,2-dibromoethane (3 g, 0.016 mol) and 4-(tert-butoxy)phenol (0.66 g, 0.004 mol). The mixture was stirred at 70° C. for 15 h before water and CHCl3 were added. The layers were separated, the organic layer washed with 10% aqueous NaOH and then dried (Na2SO4) and concentrated in vacuo to give 0.32 g (28%) of the sub-title compound.

1. temperatureto a warmed
2. additionwere added
3. customThe layers were separated
4. washthe organic layer washed with 10% aqueous NaOH
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated in vacuo