反应详情

Diethyl 2-(((4-chlorobenzyl)amino)carbonyl)malonate (Preparation 5, 33 mg) and 5-(4-morpholinylmethyl)-1,3,4-thiadiazol-2-ylamine (Preparation 4, 20 mg) are dissolved in xylene and heated to reflux for 5 h. The solvent is evaporated and the residue is triturated with ether. The resulting percipitate is filtered and dried to afford 17 mg of the title compound as a brown solid. Physical characteristics: MS (ESI+) m/z 438 (M+H)+. 1H NMR (DMSO) δ 7.42, 7.38, 4.60, 3.92, 3.62, 2.62.

1. temperatureheated
2. temperatureto reflux for 5 h
3. customThe solvent is evaporated
4. customthe residue is triturated with ether
5. filtrationThe resulting percipitate is filtered
6. customdried