Methyl iodide → HCID 22397147, compound

Participants

Reaction Steps

Potassium carbonate (2.25 g) and iodomethane (0.60 g) is added to a solution of methyl 6-methyl-1H-4,1,2-benzothiadiazine-3-carboxylate 4,4-dioxide (Preparation 39, 0.83 g) in DMF (20 mL). The mixture is stirred at room temperature for 5 hours and then added to CH2Cl2 (120 mL) and washed with water (4×100 mL). The organic layer is dried with Na2SO4, filtered and the solvent evaporated. The crude solid is recrystallized (1% CH2Cl2/MeOH) to obtain 0.74 g (85%) of the title compound as a yellow crystalline solid. Physical characteristics: MS (ESI+) m/z 269 (M+H).

Provenance & Evidence