1-Bromo-3-chloropropane → HCID 12016522, compound

Participants

Reaction Steps

A solution of Example 1A (10 g, 61.7 mmol), K2CO3 (12.7 g, 91.9 mmol), and 1-bromo-3-chloropropane (10.74 g, 68.2 mmol) in 2-butanone (100 mL) was refluxed for 24 hours, cooled to room temperature, filtered, and concentrated. The concentrate was heated to 40° C. under vacuum for three hours to afford 13.256 g (90%) of the desired product of sufficient purity for subsequent use without further purification.

Provenance & Evidence