Acetone → (2R)-1-[4-[3-[4-(Cyclopropylcarbonyl)phenoxy]propyl]-1-piperazinyl]-2-[(1-methylethyl)amino]-1-propanone

Participants

Reaction Steps

Sodium cyanoborohydride (75 mg, 1.2 mmol) was added to a room temperature solution of Example 138 (401 mg, 1 mmol) in acetone (10 mL). After stirring overnight, the reaction mixture was concentrated, and the concentrate was taken up in dichloromethane and washed with water, and brine, dried (Na2SO4), filtered, concentrated and purified by silica gel column chromatography using dichloromethane:methanol (9:1) as the eluant. The product was obtained in 25% yield.

Provenance & Evidence