化工社化工社 化学情報印刷レポート · 研究参考用
4-Methylmorpholine → Methyl 2-{methyl[(4-methylphenyl)sulfonyl]amino}acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Sarcosine methyl ester | HCID 83545 | — |
| 反応物 | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| 反応物 | DMF N-(toluene-4-sulfonyl)sarcosine | HCID 86589137 | — |
| 反応物 | HCID 178501396 | HCID 178501396 | — |
| 生成物 | Methyl 2-{methyl[(4-methylphenyl)sulfonyl]amino}acetate | HCID 3277444 | — |
反応手順
N-(Toluene-4-sulfonyl)sarcosine methyl ester was prepared from sarcosine methyl ester using the procedure described in Method 1. The title compound was prepared by coupling in DMF N-(toluene-4-sulfonyl)sarcosine with (N-benzyl)histidine methyl ester in the presence of BOP and NMM, to give after aqueous workup and flash chromatography, the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06559127B1 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-02b6740304c549cc93cc7a228ef9256d |
| 出典メモ | uspto-grants-2003_05 |