反应详情

A mixture of 2-(5-fluoro-2-trifluoromethyl-phenyl)-acetic acid (50 g), ethanol (100 ml) and concentrated sulfuric acid (4 ml) is heated at reflux for twelve hours. The solvent is distilled off in vacuo and the residue is diluted with ether. The mixture is neutralized with solid sodium bicarbonate and dried with anhydrous sodium sulphate and filtered. The filtrate is concentrated in vaouo to yield 54 g of the product.

1. temperatureis heated
2. temperatureat reflux for twelve hours
3. distillationThe solvent is distilled off in vacuo
4. additionthe residue is diluted with ether
5. dry with materialdried with anhydrous sodium sulphate
6. filtrationfiltered
7. concentrationThe filtrate is concentrated in vaouo