Ethanol → Ethyl 5-fluoro-2-(trifluoromethyl)benzeneacetate

HRID 411274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 411274
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1.S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:13])([F:14])[F:15])=[C:6]([CH2:8][C:9]([O:11][CH2:21][CH3:22])=[O:10])[CH:7]=1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 27375945-Fluoro-2-(Trifluoromethyl)Phenylacetic Acid

Produkt 1

HCID 12056799Ethyl 5-fluoro-2-(trifluoromethyl)benzeneacetate

Versuchsvorschrift

A mixture of 2-(5-fluoro-2-trifluoromethyl-phenyl)-acetic acid (50 g), ethanol (100 ml) and concentrated sulfuric acid (4 ml) is heated at reflux for twelve hours. The solvent is distilled off in vacuo and the residue is diluted with ether. The mixture is neutralized with solid sodium bicarbonate and dried with anhydrous sodium sulphate and filtered. The filtrate is concentrated in vaouo to yield 54 g of the product.

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux for twelve hours
  3. distillationThe solvent is distilled off in vacuo
  4. additionthe residue is diluted with ether
  5. dry with materialdried with anhydrous sodium sulphate
  6. filtrationfiltered
  7. concentrationThe filtrate is concentrated in vaouo

Quellen und Nachweise

ORD-Eintrag
ord-72bde45d0da84ad88900a49d092d7c52
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559151B2

Notizen zur Reaktion

Wird geladen…