Cyclopropanecarbonyl chloride → HCID 10205776, compound

Participants

Reaction Steps

A mixture of 6,7-dimethoxy-N2-(4-phenyl-piperidin-4-ylmethyl)-N2-methyl-quinazoline-2,4-diamine 11 (125 mg), ethyl acetate (10 ml) and aq. sodium bicarbonate (10 ml) was stirred vigorously while 40 μL of cyclopropylcarbonyl chloride were added slowly via syringe. After 30 min., the reaction mixture was worked up as usual to yield 1-(4-{[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-methyl}-4-phenyl-piperidin-1-yl)-1-cyclopropyl-methanone 12, MS: 476 ([M+H]+) The crude base was converted to the hydrochloride salt as a white powder (120 mg).

Provenance & Evidence