Triethylamine → HCID 10301355, compound

Participants

Reaction Steps

A solution of 6,7-dimethoxy-N2-(4-phenyl-piperidin-4-ylmethyl)-N2-methyl-quinazoline-2,4-diamine 11 (350 mg), dimethylsulfamoyl chloride (140 μl), and triethylamine (240 μl) in tetrahydrofuran (10 ml) was stirred at room temperature for 24 hours. The mixture was diluted with water and extracted with ethyl acetate. The product was chromatographed on silica gel to yield 4-{[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-methyl}-4-phenyl-piperidine-1-sulfonic acid dimethylamide 19, MS: 515 ([M+H]+).

Provenance & Evidence