Triethylamine → HCID 20583358, compound

Participants

Reaction Steps

A solution of 6,7-dimethoxy-N2-(4-phenyl-piperidin-4-ylmethyl)-quinazoline-2,4-diamine 11 (375 mg), ethyl chloroformate, and triethylamine (250 μl) in dichloromethane (10 ml) was stirred at room temperature for 24 hours. The mixture was diluted with water and extracted with ethyl acetate. The product was chromatographed on silica gel to yield 4-{[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-methyl}-4-phenyl-piperidine-1-carboxylic acid ethyl ester 20, MS: 479 (M+).

Provenance & Evidence