(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 22984557, compound

HRID 411354Notes

Reaction equation

HRID 411354 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:18][C@H:19]1[C:25]2[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=2[CH2:23][CH2:22][N:21]([CH2:31][CH3:32])[C:20]1=[O:33]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:18][C@H:19]2[C:25]3[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=3[CH2:23][CH2:22][N:21]([CH2:31][CH3:32])[C:20]2=[O:33])=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 22984556HCID 22984556, compound

Product 1

HCID 22984557HCID 22984557, compound

Procedure

Following General Procedure C above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 1-(S)-amino-3-ethyl-7-fluoro-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one (General Procedure 6-A), the title compound was prepared. Purification was by flash chromatography using 5% methanol/dichloromethane as the eluant.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-123c7e59f437447b93387dd086a97353
Source dataset
uspto-grants-2003_05
Patent number
US06559141B2

Reaction notes

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