Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one → 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one | HCID 4434433 | — |
| 반응물 | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| 생성물 | 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 10294459 | — |
반응 단계
Following General Procedure A above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (General Procedure 6-B), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.15 in 12% methanol/dichloromethane) and purification was by flash chromatography using 12% methanol/dichloromethane as the eluant.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06559141B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-a24dda8371c74f85b6c96e72d1604710 |
| 출처 메모 | uspto-grants-2003_05 |