Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)- → HCID 131723828, compound

HRID 411369Notes

Reaction equation

HRID 411369 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:13])[CH:12]=1)[C@H:5]([OH:9])[C:6]([OH:8])=O.Cl.[NH2:15][C@H:16]([C:20]([NH:22][N:23]1[C:29](=[O:30])[CH:28]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[C:27]2[CH:37]=[CH:38][CH:39]=[CH:40][C:26]=2[C:25]2[CH:41]=[CH:42][CH:43]=[CH:44][C:24]1=2)=[O:21])[CH:17]([CH3:19])[CH3:18]>>[F:13][C:11]1[CH:10]=[C:4]([CH:3]=[C:2]([F:1])[CH:12]=1)[C@H:5]([OH:9])[C:6]([NH:15][C@H:16]([C:20]([NH:22][N:23]1[C:29](=[O:30])[CH:28]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[C:27]2[CH:37]=[CH:38][CH:39]=[CH:40][C:26]=2[C:25]2[CH:41]=[CH:42][CH:43]=[CH:44][C:24]1=2)=[O:21])[CH:17]([CH3:18])[CH3:19])=[O:8]

Participants

3

Reactant 2

HCID 6951479Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-HCID 23552797HCID 23552797, compound

Product 1

HCID 131723828HCID 131723828, compound

Procedure

Following General Procedure D and using (S)-3,5-difluoromandelic acid (Example L) and 5-(L-valinyl)-amino-7-hexyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one hydrochloride (Example 7-V), the title compound was prepared. The product was purified by chromatography (silica, 5% MeOH/CHCl3).

Workup

  1. customThe product was purified by chromatography (silica, 5% MeOH/CHCl3)

Sources & evidence

ORD record
ord-9be90ac555ef4a048ad7ead9f873dada
Source dataset
uspto-grants-2003_05
Patent number
US06559141B2

Reaction notes

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