反应详情

A suspension of α-chloro-3',4'-dihydroxyacetophenone (9.33 g, 0.05 mole) in 78 ml of acetic anhydride was treated with 0.1 ml of concentrated sulfuric acid and stirred for 1.5 hours under an argon atmosphere. Initially, the reaction temperature rose to 40° C. and the starting material completely dissolved yielding a clear, colorless solution which was poured onto approximately 300 g of crushed ice. After standing for one hour, the crystallized product was filtered, washed with cold water (200 ml) and dried in vacuo overnight at room temperature; yield: 11.5 g.

1. customrose to 40° C.
2. dissolutionthe starting material completely dissolved
3. customyielding a clear, colorless solution which
4. waitAfter standing for one hour
5. filtrationthe crystallized product was filtered
6. washwashed with cold water (200 ml)
7. customdried in vacuo overnight at room temperature