(4-Nitrophenyl)acetic acid → 2-[(4Nitrophenyl)acetamido]butyric acid iso-butyl ester

HRID 411470Notes

Reaction equation

HRID 411470 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH2:14][CH:15]([CH2:23][CH3:24])[C:16]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[O:17]>>[CH2:19]([O:18][C:16](=[O:17])[CH:15]([NH:14][C:11](=[O:13])[CH2:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)[CH2:23][CH3:24])[CH:20]([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 4661(4-Nitrophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 537955052-[(4Nitrophenyl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 4-nitrophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-0ad1d9c4037a45559d56f650fcd245cb
Source dataset
uspto-grants-2003_05
Patent number
US06559141B2

Reaction notes

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