3-Thiophenacetic acid → 2-((Thien-3-yl)acetamido]butyric acid iso-butyl ester

HRID 411471Notes

Reaction equation

HRID 411471 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([OH:9])=O)=[CH:2]1.[NH2:10][CH:11]([CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]([NH:10][C:7](=[O:9])[CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[CH2:19][CH3:20])[CH:16]([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 234043-Thiophenacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 542657592-((Thien-3-yl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 3-thiopheneacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-ed402c8cba8a44eeab735acffbe88fbd
Source dataset
uspto-grants-2003_05
Patent number
US06559141B2

Reaction notes

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