HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 4-(2-Oxiranylmethoxy)benzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Cyanophenol | HCID 13019 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(2-Oxiranylmethoxy)benzenecarbonitrile | HCID 2764301 | 75% |
Reaction Steps
Epichlorohydrin (800 mL) and K2CO3 (414 g) were added to a stirred solution of p-cyanophenol (238 g) in 2.0 L MeCN and the reaction mixture was refluxed under inert atmosphere for 2 h. The hot solution was filtered and the filtrate concentrated to give a clear oil. This was crystallized from di-iso-propyl ether to give the sub-title compound in 75% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06559162B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-a9d546007ea3404495eb6b09a44c0443 |
| Source note | uspto-grants-2003_05 |