Hydrochloric Acid → 2,2,2-Trifluoro-1-[8-(methylamino)-3-azabicyclo[3.2.1]oct-3-yl]-1-ethanone

Participants

Reaction Steps

Ethyl acetate (100 mL) saturated with HCl (g) was added, at 0° C., to a solution of tert-butyl methyl[3-(2,2,2-trifluoroacetyl)-3-azabicyclo[3.2.1]oct-8-yl]carbamate (see step (iv) above; 5 g, 15 mmol) in ethyl acetate (50 mL). The mixture was allowed to reach rt over the course of 3 h, after which time the solvent was evaporated. This gave 4 g (100%) of the sub-tide compound hydrochloride salt.

Provenance & Evidence