HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Edukt | Acetic Anhydride | HCID 7918 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 1-Acetyl-4-(2-hydroxyethyl)piperazine | HCID 4739629 | 65% |
Reaktionsschritte
A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06559162B2 |
| Quelldatensatz | uspto-grants-2003_05 |
| ORD ID | ord-719de8e84b1941b0afa086c4c952fcc5 |
| Quellennotiz | uspto-grants-2003_05 |