Acetonitrile → N-{3-[2-(4-Cyanophenoxy)ethyl]-3-azabicyclo[3.2.1]oct-8-yl}-N'-ethyl-N-methylurea

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Reaction Steps

A solution of ethyl isocyanate (0.8 mL, 9.66 mmol) in DCM (3 mL) was added dropwise, at 0° C., to a mixture of 4-{2-[8-(methylamino)-3-azabicyclo[3.2.1]oct-3-yl]ethoxy}benzonitrile (Preparation K; 2.5 g, 8.76 mmol) and MeCN (50 mL). The mixture was stirred at rt for 3 h, K2CO3 (2 g, 14.4 mmol) was added and the mixture was stirred for a further 2 h. Filtration and evaporation gave 2.96 g of crude product. This was purified twice by chromatography on silica gel, the first time eluting with a gradient of EtOAc:MeOH:ammoniacal methanol (10:1:0 to 10:0:1), and the second time eluting with DCM:MeOH:TEA (190:10:1). This gave 2.3 g (71.4%) of the title compound.

Provenance & Evidence