反应详情

1.32 g of 2-(phenoxyacetyl)aminopyridine HCl salt (5 mmole) was resuspended in 10 ml of dichloromethane and 2 ml of chlorosulfonic acid was added in ice-bath to give clear solution. The solution was stirred at room temperature for 3 hr. The reaction mixture was added to ice-water with good stirring to give white solids. The solids were filtered, washed with acetonitrile, and dried in vacuo. 0.65 g of solid was obtained. M. P. 170-175° C. (decomposition)

1. customto give clear solution
2. stirringwith good stirring
3. customto give white solids
4. filtrationThe solids were filtered
5. washwashed with acetonitrile
6. customdried in vacuo