Chlorosulfonic acid → HCID 18541183, compound

Participants

Reaction Steps

Preparation of N-(carbamoylmethyl)-2-[4-(chlorosulfonyl)phenoxy]acetamide N-(carbamoylmethyl)-2-(phenoxy)acetamide (2.08 g) was resuspended in 30 ml of dichloromethane and chlorosulfonic acid (6 ml) was slowly added with cooling. The reaction mixture was stirred at room temperature for 2 hr. Two layers separated after standing for 10 min without stirring. Upper layer was decanted. Lower layer was poured to chopped ice (60 g) with good mixing to give white solid, which was collected by filtration and washed with ice-cold water. The solid was dried in vacuo to give 2.78 g of N-(carbamoylmethyl)-2-[4-(chlorosulfonyl)phenoxy]acetamide.

Provenance & Evidence