2-Thiophenecarboxaldehyde → HCID 69557079, compound

HRID 411622Notes

Reaction equation

HRID 411622 reaction equation
[S:1]([CH2:11][N+:12]#[C-:13])([C:4]1[CH:10]=[CH:9][C:7](C)=[CH:6][CH:5]=1)(=[O:3])=[O:2].[S:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[CH:19]=[O:20].[C-:21]#N.[Na+]>CCO>[S:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[C@@H:19]1[O:20][CH:13]=[N:12][C@@H:11]1[S:1]([C:4]1[C:5]([CH3:21])=[CH:6][CH:7]=[CH:9][CH:10]=1)(=[O:2])=[O:3]

Participants

5

Reactant 3

HCID 73642-ThiophenecarboxaldehydeHCID 8929Sodium CyanideHCID 161915Tosylmethyl isocyanide

Product 1

HCID 69557079HCID 69557079, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of tosylmethylisocyanide (0.75 g, 3.84 mmol), 2-thiophenecarboxaldehyde (0.37 mL, 3.96 mmol) and sodium cyanide (0.02 g, 0.40 mmol) in EtOH (10 mL) was stirred at room temperature for 2 h. The solvent was removed to give the desired compound as a tan solid. This material was used without further purification. MS(ES+) m/z 614.8 (2M+H+).

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-1eb5b9d39ab6457cb9a167016e8232b1
Source dataset
uspto-grants-2003_05
Patent number
US06559172B1

Reaction notes

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