HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic Acid → HCID 10587069, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic Acid | HCID 760 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Phenethylamine, (+)- | HCID 643189 | — |
| Reactant | HCID 11022211 | HCID 11022211 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | HCID 10587069 | HCID 10587069 | — |
Reaction Steps
(R)-1-Phenyl-ethylamine (1.5 equivalents), glyoxylic acid (1.3 equivalents) and K2CO3 (2.5 equivalents) are combined in DMF. After 3h, add the 3-[1-isocyano-1-(toluene-4-sulfonyl)-methyl]-thiophene (1 equivalent) and stir the reaction at RT for 18 h. Pour the reaction mixture into brine and extract with Et2O. Dry the combined organic extracts over K2CO3 and isolate the desired product by flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06559172B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-eb83ca272c6545e98d97bcbf822be511 |
| Source note | uspto-grants-2003_05 |