反应详情

The starting methyl ether 18 (0.55 g, 2.1 mmol) was heated at 200° C. with Pyr-HCl (5 g) for one hour. The reaction mixture was allowed to cool to rt and worked up by partitioning between 2N HCl and EtOAc/MeOH. The organic layer was washed with NaHCO3 aq and brine and dried over MgSO4. Concentration gave 24 (0.29 g) as a tan solid: MP>300° C.; 1H NMR (DMSO-d6) δ 11.2 (br s, 1H), 8.14-8.07 (m, 2H), 7.87 (d, 1H, J=8.5 Hz), 7.76-7.70 (m, 1H), 7.55-7.52 (m, 1H), 7.09 (d, 1H, J=1.9 Hz), 7.02 (dd, 1H, J=8.8 Hz, 1.9 Hz); MS APCI 253 (M+H)+.

1. customby partitioning between 2N HCl and EtOAc/MeOH
2. washThe organic layer was washed with NaHCO3 aq and brine
3. dry with materialdried over MgSO4
4. concentrationConcentration