Hydrazine → HCID 178489814, compound

HRID 411699Notes

Reaction equation

HRID 411699 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9](=O)[CH2:10][C:11]#[N:12])[CH:6]=[CH:7][CH:8]=1.[NH2:14][NH2:15]>CCO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([NH2:12])[NH:14][N:15]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 5847163-(3-Methoxyphenyl)-3-oxopropanenitrile

Product 1

HCID 178489814HCID 178489814, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(3-Methoxy-phenyl)-3-oxo-propionitrile (2.0202 gms.) is then suspended in 55 mL of anhydrous EtOH. This suspension is treated with 0.73 mL of anhydrous hydrazine and subsequently heated to refluxing temperature for 1 day. The reaction mixture is concentrated in vacuo. The residue is then triturated with isopropanol to precipitate out the 5-(3-methoxy-phenyl)-2H-pyrazol-3-ylamine as a white solid.

Workup

  1. temperaturesubsequently heated
  2. temperatureto refluxing temperature for 1 day
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. customThe residue is then triturated with isopropanol
  5. customto precipitate out the 5-(3-methoxy-phenyl)-2H-pyrazol-3-ylamine as a white solid

Sources & evidence

ORD record
ord-7a04ae81653d45c083f1248453501ccf
Source dataset
uspto-grants-2003_05
Patent number
US06559173B1

Reaction notes

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