Acetic Acid → HCID 18541329, compound

Participants

Reaction Steps

T a stirred solution of ethyl[4-(2,6-dichlorobenzyloxy)benzylidene]malonate (8.35 g, 19,2 mmol) in ethanol at 0° C. under argon was added sodium borohydride in small portions. Upon completion of the addition, the reaction mixture was adjusted to pH 6 with acetic acid. The mixture was filtered, concentrated in vacuo then partitioned between ether and water. The organic extract was washed successively with 1N hydrochloric acid, saturated sodium bicarbonate solution, water, brine and dried (MgSO4). Removal of volatiles in vacuo afforded the title compound (7.47 g, 88%).

Provenance & Evidence