Potassium Hydroxide → HCID 70021605, compound

Participants

Reaction Steps

A solution of diethyl[4-(2,6-dichlorobenzyloxy)benzyl]malonate (3.02 g, 7.1 mmol) in ethanol (70 mL) with potassium hydroxide (0.48 g, 7.4 mmol) was stirred at room temperature for 18 h. The reaction mixture was diluted with water (100 mL) then concentrated to half the original volume in vacuo. The resulting aqueous solution was washed with ether then acidified with 3N HCl and the product extracted into ethyl acetate. The organic extract was washed with water then brine and dried (Na2SO4). Removal of solvent in vacuo afforded the title compound (2.86 g, 100%)

Provenance & Evidence