Piperidin-4-ol → 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(4-hydroxypiperidine-1-carbonyl)-2-morpholino-4H-chromen-4-one

Participants

Reaction Steps

Title compound was prepared using an analogous procedure to that described in Example 1.01. 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid (105 mg, 0.21 mmol) was reacted with piperidin-4-ol (22.48 mg, 0.22 mmol) to afford 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(4-hydroxypiperidine-1-carbonyl)-2-morpholino-4H-chromen-4-one (75 mg, 66%) as a white solid.

Provenance & Evidence