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A solution of 4,4′-dimethoxytrityl chloride (695 mg, 2.05 mmol) and 4-hydroxybutyric acid (208 mg, 2.0 mmol) in anhydrous Pyridine (20 mL) was stirred overnight and concentrated to an oil in vacuo. The residue was dissolved in a mixture of MeOH and CH2Cl2 (95:5, v/v; 200 mL) and washed with 2M aqueous triethylammonium acetate (5×20 mL). The organic solution was evaporated, re-dissolved in CH2Cl2, dried over Na2SO4, and evaporated to give the crude title compound in a quantitative yield (1016 mg).

1. concentrationconcentrated to an oil in vacuo
2. dissolutionThe residue was dissolved in a mixture of MeOH and CH2Cl2 (95:5
3. wash200 mL) and washed with 2M aqueous triethylammonium acetate (5×20 mL)
4. customThe organic solution was evaporated
5. dissolutionre-dissolved in CH2Cl2
6. dry with materialdried over Na2SO4
7. customevaporated