HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 4-Piperazinyl-2,6-bis-hydroxymethyl pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Calcium Chloride | HCID 5284359 | — |
| Reactant | Diethyl-4-piperazinyl-2,6-pyridinedicarboxylate | HCID 85702736 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 4-Piperazinyl-2,6-bis-hydroxymethyl pyridine | HCID 21257329 | — |
Reaction Steps
Diethyl-4-piperazinyl-2,6-pyridinedicarboxylate is dissolved in THF and treated with NaBH4 and CaCl2. Brine is added and the organic phase is separated. The organic phase is washed with brine, dried (Na2SO4) and the solvent is evaporated. The residue is purified by flash chromatography on a silica gel column to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06559303B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-602c02c2f14a4ed7a246a7f6ec650972 |
| Source note | uspto-grants-2003_05 |