Ethanol → 2-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

HRID 411912Notes

Reaction equation

HRID 411912 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:16])([CH3:15])[C:13]#[N:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1.C([OH:19])C.O>[OH-].[K+]>[CH:1]1([C:4]([C:6]2[CH:7]=[CH:8][C:9]([C:12]([CH3:16])([CH3:15])[C:13]([NH2:14])=[O:19])=[CH:10][CH:11]=2)=[O:5])[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 702EthanolHCID 962WaterHCID 234998454-(Cyclopropylcarbonyl)-alpha,alpha-dimethylbenzeneacetonitrile

Product 1

HCID 234998512-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent2×

Procedure

Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile (100 mg in aqueous ethanolic potassium hydroxide (2 mL) (prepared from ethanol (5 mL), water (5 mL) and solid potassium hydroxide (1.5 g). Stir overnight at room temperature, then heat at reflux for 6 hours. Cool and evaporate the solvent in vacuo to give the title compound.

Workup

  1. temperatureheat
  2. temperatureat reflux for 6 hours
  3. temperatureCool
  4. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-6faf4c88153a4749b512178615212b83
Source dataset
uspto-grants-2003_05
Patent number
US06559312B2

Reaction notes

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