3-Bromoaniline → N-(3-Bromophenyl)-6-nitroquinazolin-4-amine

Participants

Reaction Steps

In one particular, 3-bromoaniline is reacted with 4-chloro-6-nitroquinazoline to produce 4-[(3-bromophenyl)amino]-6-nitro quinazoline, which is reduced thereafter, by means of an ethanolic solution of hydrazine hydrate and Raney®Nickel, to the corresponding 6-aminoquinazoline. The 4-[(3-bromophenyl)amino]-6-aminoquinazoline is then reacted with bistributyltin in the presence of tetrakis(triphenylphosphine)palladium in triethylamine solution and the obtained stanylated product is reacted thereafter with bromine-76, as described hereinabove. The obtained bromine-76 labeled 4-[(3-bromophenyl)amino]-6-aminoquinazoline is then reacted with an acryloyl chloride to produce a bromine-76 labeled {4-[(3-bromophenyl)amino]quinazoline-6-yl}acrylamide.

Provenance & Evidence