1,4-Dioxane hydrochloride → (r)-5,11-Dihydro-5-[1-[2-(4-dimethylaminophenyl)ethyl]-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 411966Notes

Reaction equation

HRID 411966 reaction equation
[ClH:1].O1CCOCC1.[CH3:8][N:9]([CH3:39])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][C@@H:19]2[CH2:23][N:24]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[CH2:28][O:27][C:26]3[CH:35]=[CH:36][CH:37]=[CH:38][C:25]2=3)=[CH:12][CH:11]=1>ClCCl>[ClH:1].[ClH:1].[CH3:39][N:9]([CH3:8])[C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][C@@H:19]2[CH2:23][N:24]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[CH2:28][O:27][C:26]3[CH:35]=[CH:36][CH:37]=[CH:38][C:25]2=3)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59062716(r)-5,11-Dihydro-5-[1-[2-(4-dimethylaminophenyl)ethyl]-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine

Product 1

HCID 69948030(r)-5,11-Dihydro-5-[1-[2-(4-dimethylaminophenyl)ethyl]-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.6 ml of 4 M hydrochloride/dioxane was added to a solution of 238 mg of (R)-5,11-dihydro-5-[1-[2-(4-dimethylaminophenyl)ethyl]-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine in dichloromethane (10 ml), and the solution was stirred for 5 minutes. The solvent was evaporated under reduced pressure, and the residue was recrystallized from a mixed solvent of ethanol, dimethoxyethane and ether to obtain the title compound in the form of a white solid (204 mg, 73%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized from a mixed solvent of ethanol, dimethoxyethane and ether

Sources & evidence

ORD record
ord-563705532a3a4e6999eac68ea58fcf76
Source dataset
uspto-grants-2003_05
Patent number
US06562808B1

Reaction notes

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