1-Methylpiperazine → 8-[(2R)-(1-(3-fluorophenyl)pyrrolidin-2-yl)]-6-(4-methylpiperazine-1-carbonyl)-2-morpholino-4H-chromen-4-one

Participants

Reaction Steps

8-[(2R)-(1-(3-fluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid (see Example 1.06 for preparation; 100 mg, 0.23 mmol) was reacted with 1-methylpiperazine (0.076 ml, 0.68 mmol) using a procedure similar to the one described in example 1.00 to afford 8-[(2R)-(1-(3-fluorophenyl)pyrrolidin-2-yl)]-6-(4-methylpiperazine-1-carbonyl)-2-morpholino-4H-chromen-4-one (39 mg, 33%).

Provenance & Evidence