3-Bromoanisole → methyl 8-[(2R)-(1-(3-methoxyphenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylate

Participants

Reaction Steps

Methyl 2-morpholino-4-oxo-8-[(2R)-pyrrolidin-2-yl]chromene-6-carboxylate, preparation described in Example 1.03b, 125 mg, 0.35 mmol) was reacted with 1-bromo-3-methoxybenzene (0.049 ml, 0.38 mmol) using a procedure similar to that described in Example 1.0 to afford methyl 8-[(2R)-(1-(3-methoxyphenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylate (90 mg, 56%) as a yellow gum. Mass Spectrum: m/z [M+H]+=465.

Provenance & Evidence