Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Aminopropanol | HCID 5126 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | HCID 18536250 | HCID 18536250 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18536259 | HCID 18536259 | — |
Reaction Steps
The product of Example 2 (0.3 g) was dissolved in N,N-dimethylformamide (3 ml). 1,1′-Carbonyldiimidazole (0.1 g) and 2-amino-1-propanol (5 molar equivalents) were added, the solution heated at 60° C. for 1.5 hours and cooled. Water and ether were added, the organic phase separated and concentrated to a gum which was purified by chromatography (dichloromethane:methanol, 9:1) to give the product as a solid (0.15 g), m.p. 115-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06562825B1 |
|---|
| Source dataset | uspto-grants-2003_05 |
|---|
| ORD ID | ord-9b9c26ca6c0d4068a2b897f7951f116b |
|---|
| Source note | uspto-grants-2003_05 |
|---|
