3-Methoxy-2-nitrobenzamide → 2-Amino-3-methoxybenzamide

Participants

Reaction Steps

3-Methoxy-2-nitrobenzamide (7.0 g, 0.038 mol) was dissolved in ethanol (150 ml) and the solution stirred with Raney nickel catalyst (0.5 g) under a hydrogen atmosphere at 50 p.s.i. (3.45 bar) for 4 hours. The catalyst was removed by filtration and the solvent removed by evaporation under vacuum to give the title compound, after crystallization from ethyl acetate-hexane, as a colourless solid (6.3 g, 83%), m.p. 140-141° C.

Provenance & Evidence