Chlorosulfonic acid → HCID 15269533, compound

HRID 412056Notes

Reaction equation

HRID 412056 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:13])[CH:7]=[CH:8][N:9]2[CH3:12])=[CH:4][CH:3]=1.[Cl:14][S:15](O)(=[O:17])=[O:16]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:13])[C:7]([S:15]([Cl:14])(=[O:17])=[O:16])=[CH:8][N:9]2[CH3:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 11074270HCID 11074270, compound

Product 1

HCID 15269533HCID 15269533, compound

Conditions

Temperature
140 °C

Procedure

7-Chloro-1-methyl-4-quinolone (6.9 g) and chlorosulphonic acid (14 ml) can be stirred and heated at 140° C. for 2 hours. The reaction mixture can be cooled to room temperature and carefully added dropwise to ice water (200 ml). The solid which forms can be collected, washed with water and dried in air to give the compound 7-chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-sulphonyl chloride, m.p. >300° C.

Workup

  1. temperatureThe reaction mixture can be cooled to room temperature
  2. customThe solid which forms can be collected
  3. washwashed with water
  4. customdried in air

Sources & evidence

ORD record
ord-0d3cd2e731c141c0969231a4d4ca6fc3
Source dataset
uspto-grants-2003_05
Patent number
US06562838B2

Reaction notes

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