HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexahydro-1,4-diazepine → HCID 16795380, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexahydro-1,4-diazepine | HCID 68163 | — |
| Reactant | Ethyl chloronicotinate | HCID 2796614 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 16795380 | HCID 16795380 | 83% |
Reaction Steps
10.0 g of ethyl 2-chloronicotinate were heated to reflux for 2 h with 21.6 g of homopiperazine in 150 ml of ethanol. After removing the solvent, the residue was partitioned between NaCl solution and ethyl acetate and the aqueous phase was extracted several times with ethyl acetate. The combined organic phases were dried over magnesium sulfate and concentrated, 11.1 g (83%) of the product being obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06562827B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-3463ca04b6eb4d278bd722214f9afce8 |
| Source note | uspto-grants-2003_05 |