Phenyl isocyanate → HCID 18536729, compound

HRID 412073Notes

Reaction equation

HRID 412073 reaction equation
[OH:1][CH2:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][C:17]=2[C:18]([F:21])([F:20])[F:19])[NH:14][C:13](=[O:22])[C:12]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:11]3)[CH:7]=1.[C:28]1([N:34]=[C:35]=[O:36])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[O:22]=[C:13]1[C:12]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:11][C:10]2[C:15](=[CH:16][C:17]([C:18]([F:20])([F:21])[F:19])=[C:8]([N:6]3[CH:7]=[C:3]([CH2:2][O:1][C:35](=[O:36])[NH:34][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[N:4]=[CH:5]3)[CH:9]=2)[NH:14]1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 9951850HCID 9951850, compound

Product 1

HCID 18536729HCID 18536729, compoundYield 89.1%

Procedure

Using the compound of Example 17 (200 mg, 525 μmol) and phenyl isocyanate (93.9 mg, 0.788 mmol), and through the process similar to Example 18, 234 mg of title compound were obtained as colorless powder. Yield 89%.

Sources & evidence

ORD record
ord-cc83d818fe8547c7aa37b69fe52d195d
Source dataset
uspto-grants-2003_05
Patent number
US06562839B1

Reaction notes

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