Sodium borohydride → HCID 18536726, compound

HRID 412075Notes

Reaction equation

HRID 412075 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:8]([O:12][CH2:13][CH3:14])=[N:9]2)=[CH:4][C:3]=1[N:20]1[CH:24]=[C:23]([CH:25]=[O:26])[N:22]=[CH:21]1.[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:8]([O:12][CH2:13][CH3:14])=[N:9]2)=[CH:4][C:3]=1[N:20]1[CH:24]=[C:23]([CH2:25][OH:26])[N:22]=[CH:21]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18536737HCID 18536737, compound

Product 1

HCID 18536726HCID 18536726, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound of Example 34 (1.91 g, 5.11 mmol) in ethanol (30 ml) was added sodium borohydride (96.8 mg, 2.56 mmol), and the mixture was stirred for 6 hours at room temperature. After concentrated the reaction mixture, the residue obtained was washed with water and then dried under reduced pressure, thereby obtaining 740 mg of title compound as light brown powder. Yield 39%.

Workup

  1. concentrationAfter concentrated the reaction mixture
  2. customthe residue obtained
  3. washwas washed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-84125b18ebf04e3aa6d7b3201ed87718
Source dataset
uspto-grants-2003_05
Patent number
US06562839B1

Reaction notes

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