Phenyl isocyanate → HCID 18536755, compound

Participants

Reaction Steps

To a suspension of the compound of Example 36 (100 mg, 288 μmol) in ethyl acetate (5 ml) were added phenyl isocyanate (68.6 mg, 576 μmol) and successively triethylamine (58.3 mg, 576 μmol), and the mixture was refluxed for 24 hours. After cooling, the precipitated crystals were collected by filtration, washed with ethyl acetate and water in sequence, and then dried under reduced pressure, thereby obtaining 44.0 mg of title compound as colorless powder. Yield 33%.

Provenance & Evidence